Ключевые слова: synthesis of vitamin A derivatives and its analogues; methods for creating multiple bonds (olefination by Wittig, Horner-Emmons) in polyene compounds (retinoids and carotenoids); retinoid-protein complexes: bacteriorhodopsin and nuclear receptors of retinoic acid; obtaining natural compounds and their analogues labeled with stable isotopes; technical devices based on bacteriorhodopsin and its derivatives, biomolecular electronics; antiaggregational agents based on isoxazole derivatives; methods for synthesis of heterocyclic compounds of pyridine and isoxazole series