Эта публикация цитируется в 10 статьях

Communications

Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem

J. Sun^a, L. He^a, Yu. Gao^a, L. Zhai^a, J. Ji^a, Yu. Liu^a, J. Ji^a, X. Ma^b, Ya. Mu^a, D. Tang^a, H. Yang^a, Z. Iqbal^a, Zh. Yang<sup>a

a</sup> Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, Ningxia, P.R. China
^b College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, P.R. China

Аннотация: New avibactam derivatives in which amide moiety is replaced by substituted amidine groupings were obtained in several steps, the key step having involved the conversion of 2-positioned cyano group of the 1,6-diazabicyclo[3.2.1]-octane framework into the amidine one. Synergistic antibacterial activity of the new compounds in combination with meropenem infers the agonistic effect of these derivatives against β-lactamases.

Язык публикации: английский

DOI: 10.1016/j.mencom.2021.07.020

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