Communications

Comparison of nonstoichiometric and Mg-containing calcium-deficient hydroxyapatites obtained by enzymatic synthesis

G. S. Mikhaylov^a, I. I. Gerasimova^a, D.-M. V. Ratova^a, I. V. Mikheev^a, O. I. Klein^b, M. G. Chernysheva^a, G. A. Badun<sup>a

a</sup> Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation.
^b Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russian Federation

Аннотация: Enzymatic synthesis of calcium phosphate in Tris buffer with MgCl₂ results in a two-fold increase in product yield compared to synthesis in water. Although some calcium positions are substituted with magnesium, both samples are classified as depleted hydroxyapatite. The Mg-containing sample exhibits higher aggregation capacity at high concentrations, resulting in reduced antimicrobial activity against gram-positive Bacillus strains.

Ключевые слова: enzymatic hydroxyapatite, Mg-substituted hydroxyapatite, antimicrobial activity, FTIR, ICP-AES.

Поступила в редакцию: 20.08.2025
Принята в печать: 24.10.2025

Язык публикации: английский

DOI: 10.71267/mencom.7901