Communications

A convenient synthesis of dihydropyridinone dicarboxylic derivatives by the recyclization of N-arylitaconimides with 3-aminocrotonates

Yu. A. Kovygin^a, Ya. Yu. Kulichikhina^a, I. S. Zotova^a, K. O. Karelina^a, M. A. Prezent^b, A. N. Fakhrutdinov^b, Kh. S. Shikhaliev<sup>a

a</sup> Department of Chemistry, Voronezh State University, 394018 Voronezh, Russian Federation
^b N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Аннотация: N-Arylitaconimides undergo smooth recyclization with 3-aminocrotonic esters to afford 6-alkyl-3-(2-anilino-2-oxoethyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxylates when heated in acetic acid. The product structure has been established by NMR, which allows one to rule out the formation of other alternative heterocyclic derivatives.

Ключевые слова: itaconimides, enamines, aminoalkenoates, pyridones, hetarylacetanilides, recyclization, domino reaction

Поступила в редакцию: 08.04.2025
Принята в печать: 09.06.2025

Язык публикации: английский

DOI: 10.71267/mencom.7794

Реферативные базы данных:

•