Communications

Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA

N. S. Volkova^a, A. A. Larenkov^b, N. S. Boutakova^a, E. K. Beloglazkina^a, A. E. Machulkin<sup>a

a</sup> Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russian Federation

Аннотация: Conjugate containing fragments of pteroic acid, anti-inflammatory drug ibuprofen, macrocyclic chelator DOTA-GA and (His-Glu)₂ moiety has been synthesized. Key structural motifs of this compound were introduced to optimize the pharmacokinetic characteristics of the pteroic acid-based conjugate. The complexation of the conjugate with radioactive lutetium-177 provided radiochemical yield of >99% and radiochemical purity of 97.6%.

Ключевые слова: folate receptors, conjugates, delivery, peptide, pteroic acid, peptide synthesis, DOTA-GA.

Поступила в редакцию: 14.03.2025
Принята в печать: 04.07.2025

Язык публикации: английский

DOI: 10.71267/mencom.7764

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