Communications

Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin

A. Yu. Usanyov^a, S. M. Sukoreva^a, N. V. Prokopova^a, M. A. Gradova^b, N. Yu. Karpechenko^cd, N. A. Bragina^a, K. A. Zhdanova<sup>a

a</sup> M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, 119571 Moscow, Russian Federation
^b N. N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation
^c N. N. Blokhin National Medical Research Center of Oncology, 115522 Moscow, Russian Federation
^d N. I. Pirogov Russian National Research Medical University, 117997 Moscow, Russian Federation

Аннотация: New conjugate of meso-aryl-substituted porphyrin and 2-deoxy-D-glucose was synthesized via the Cu-catalyzed azide–alkyne cycloaddition between azido-containing sugar and tetraethynyl-substituted porphyrin. The conjugate exhibits nanomolar photoinduced toxicity, namely, the IC₅₀ for MCF7 cells is 42 nM, and the IC₅₀ dark/IC₅₀ light ratio is 71.

Ключевые слова: synthesis, meso-arylporphyrins, 2-deoxy-D-glucose, click reaction, antitumor activity, photodynamic therapy, photosensitizer.

Поступила в редакцию: 04.04.2025
Принята в печать: 29.05.2025

Язык публикации: английский

DOI: 10.71267/mencom.7791

Реферативные базы данных:

•