Communications

One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates

X. He^a, T. Yuan^a, J. Sui^b, Sh. Dong^a, Z. Wang^a, D. Liu^a, Y. Zou<sup>c

a</sup> School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, 213164 Changzhou, P. R. China
^b Nanjing Customs Testing Center for Dangerous Goods and Packaging, 213100 Changzhou, P. R. China
^c Department of Medicinal Chemistry, China Pharmaceutical University, 210009 Nanjing, P. R. China

Аннотация: A convenient one-pot synthesis of acetylated quinolines/isoquinolines/pyridines involves the sodium-promoted Claisen condensation of the corresponding ethyl hetarenecarboxylates with ethyl acetate as the reactant and the solvent. The thus formed intermediate ethyl 3-hetaryl-3-oxopropanoates can be decarboxylated in the same reactor by refluxing with 25% H₂SO₄ to afford the title products in good to excellent yields.

Ключевые слова: acetylquinolines, acetylisoquinolines, acetylpyridines, acetylation, Claisen condensation, one-pot synthesis, solvent-free process.

Поступила в редакцию: 17.02.2025
Принята в печать: 14.03.2025

Язык публикации: английский

DOI: 10.71267/mencom.7748

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