Communications

Synthesis and antitumor activity of bis-camptothecin ester of succinic acid

N. M. Chobanov^a, L. U. Dzhemileva^a, K. O. Vakhnin^b, U. M. Dzhemilev^a, V. A. D’yakonov<sup>a

a</sup> N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

Аннотация: New succinic diester containing two residues of antitumor alkaloid camptothecin has been synthesized. Its cytotoxicity and effect on cell cycle and induction of apoptosis were explored using modern methods of flow cytometry, as well as in vitro studies of the inhibitory activity against human topoisomerase I.

Ключевые слова: camptothecin, succinic diester, hybrid molecules, cytotoxicity, cell cycle, apoptosis, topoisomerase I inhibitors, antitumor activity, flow cytometry.

Поступила в редакцию: 09.10.2024
Принята в печать: 05.12.2024

Язык публикации: английский

DOI: 10.71267/mencom.7641

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