Эта публикация цитируется в 2 статьях

Communications

A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells

N. Yu. Zyk^a, A. Yu. Kolchanova^a, N. S. Volkova^a, A. A. Uspenskaia^a, D. A. Skvortsov^a, E. K. Beloglazkina^a, N. V. Zyk^a, A. G. Majouga^b, A. E. Machulkin<sup>ac

a</sup> Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation
^c Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation

Аннотация: A conjugate for co-delivery of ispinesib and monomethyl auristatin E was prepared using methods of peptide synthesis and azide–alkyne cycloaddition. Cytotoxicity studies of the mentioned drug pair were performed. In vitro studies of the synthesized bimodal conjugate were conducted on prostate cancer cell lines.

Ключевые слова: prostate cancer, prostate specific membrane antigen, bimodal conjugates, monomethyl auristatin E, ispinesib, peptide synthesis, azide–alkyne cycloaddition.

Поступила в редакцию: 21.10.2024
Принята в печать: 05.12.2024

Язык публикации: английский

DOI: 10.71267/mencom.7661

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