Communications

Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids

S. V. Gladnev^ab, M. L. Levit^b, T. B. Tennikova^a, E. G. Korzhikova-Vlakh<sup>ab

a</sup> Institute of Chemistry, St. Petersburg State University, 198504 St. Petersburg, Russian Federation
^b Institute of Macromolecular Compounds, Branch of B. P. Konstantinov Petersburg Nuclear Physics Institute of National Research Centre ‘Kurchatov Institute’, 199004 St. Petersburg, Russian Federation

Аннотация: Bioinspired copolymers consisting of a glycopolymer main chain grafted with polylysine were synthesized using metal-free click chemistry based on a 1,3-dipolar cycloaddition reaction involving strained cyclic alkyne. Poly(2-deoxy-2- methacrylamido-d-glucose)-graft-polylysine was efficiently complexed with a double-stranded oligonucleotide duplex. The cytotoxicity of the polyplex was lower than that of the free copolymer.

Ключевые слова: bioinspired copolymers, synthetic glycopolymers, polypeptides, graft copolymers, metal-free click chemistry, delivery systems, nucleic acids.

Поступила в редакцию: 02.09.2024
Принята в печать: 02.12.2024

Язык публикации: английский

DOI: 10.71267/mencom.7606

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