Эта публикация цитируется в 2 статьях

Communications

Novel platinum(IV) prodrugs with tetraacetylriboflavin axial ligand possessing enhanced light-induced toxicity

D. V. Spector^a, R. A. Akasov^bc, D. M. Mazur^a, V. A. Roznyatovsky^a, Yu. K. Grishin^a, E. K. Beloglazkina^a, O. O. Krasnovskaya<sup>a

a</sup> Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b Moscow Pedagogical State University, 129226 Moscow, Russian Federation
^c I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russian Federation

Аннотация: Novel triple-action photoactivatable Pt^IV prodrugs were obtained by modification of Riboplatin, a cisplatin-based prodrug bearing tetraacetylriboflavin in axial position. The modification involved incorporation of either Naproxen or albumin vector maleimide residues onto the second axial position of Riboplatin. The Pt^IV prodrugs thus obtained possess improved pharmacokinetic, biological and photoactivating properties.

Ключевые слова: riboflavin, platinum(IV) prodrug, cisplatin, PDT, optical visualization, controlled release.

Поступила в редакцию: 09.10.2024
Принята в печать: 21.11.2024

Язык публикации: английский

DOI: 10.71267/mencom.7643

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