Communications

Mild cuprous halide mediated direct C³ monohalogenation of indoles

X. He^a, J. Sui^b, J. Xu^a, Z. Wang^a, T. Yuan^a, D. Liu^a, L. Wang^a, Q. Zhu<sup>c

a</sup> School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, 213164 Changzhou, P.R. China
^b Nanjing Customs Testing Center for Dangerous Goods and Packaging, 213100 Changzhou, China
^c Department of Medicinal Chemistry, China Pharmaceutical University, 210009 Nanjing, China

Аннотация: Treatment of indoles with cuprous halide–N-fluorobenzenesulfonimide system in MeCN at room temperature affords the corresponding C³-halogenated derivatives. Cuprous halide acts as a dual-function reagent serving both as the halogen source and the promoter.

Ключевые слова: indole derivatives, halogenation, cuprous halide, N-fluorobenzenesulfonimide, mild conditions.

Поступила в редакцию: 02.09.2024
Принята в печать: 16.10.2024

Язык публикации: английский

DOI: 10.71267/mencom.7609

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