This article is cited in 2 papers

Physics

Spectral studies of interaction of TAlPyP(4) and AgTAlPyP(4) with poly(rG)poly(rC), poly(rI)poly(rC) and poly(rA)poly(rU)

A. A. Ghazaryan, Y. B. Dalyan, S. G. Haroutiunian, T. V. Chalikian

Chair of Molecular Physics YSU, Armenia

Abstract: The interaction of TAlPyP(4) and AgTAlPyP(4) with poly(rG)poly(rC), poly(rI)poly(rC) and poly(rA)poly(rU) was studied by the CD and fluorescence spectral changes. Nonmetalloporphyrins bind to poly(rG)poly(rC) with two modes, preferring the intercalation to the external mode. They bind to poly(rA)poly(rU) preferentially in an outside manner and bind to poly(rI)poly(rC) in two types of binding modes. In contrast Ag-containing metalloporphyrin bind with the studied RNAs via outside mode. By the intensity of the interaction with porphyrins the studied RNAs can be placed in the following order: poly(rI)poly(rC)$\geq$poly(rA)poly(rU)>poly(rG)poly(rC).

UDC: 577.3

Received: 05.04.2005
Accepted: 29.04.2005