This article is cited in 3 papers

Physics

Mitoxantrone interaction with $\mathrm{poly(G)}$

A. T. Karapetyan^a, Yu. S. Babayan^a, M. A. Torosyan^a, M. A. Shahinyan<sup>b

a</sup> National university of architecture and construction of Armenia
^b Yerevan State University

Abstract: In the present work the thermodynamic studies of mitoxantrone complexformation with four-stranded $\mathrm{poly(G)}$ have been carried out. The binding thermodynamic parameters, the binding constant $K$ and the number of nucleotides corresponding to one binding site $n$, were determined. It was shown that mitoxantrone is bound stronger with four-stranded $\mathrm{poly(G)}$, then it is bound with double-stranded helix. It was also shown that due to difficulties of the intercalation of mitoxantrone molecules into four-stranded structure is bound mainly by external binding mode with $[\mathrm{poly(G)}]_4$ and at the interaction saturation mitoxantrone bound to much more guanines ($n\cong10$) per one molecule.

Keywords: four-stranded structure, $[\mathrm{poly(G)}]_4$, mitoxantrone, complex-formation, absorption spectrum, thermodynamic binding parameters.

Received: 01.09.2015
Accepted: 29.09.2015

Language: English