This article is cited in 1 paper

The central regulatory circuit of the morphogenesis system drosophila mechanoreceptors: mutation effects

D. P. Furman^ab, T. A. Bukharina^ab, V. P. Golubyatnikov<sup>c

a</sup> Federal Research Center Institute of Cytology and Genetics SB RAS, pr. Lavrentieva 10, Novosibirsk 630090, Russia
^b Novosibirsk State University, ul. Pirogova 1, Novosibirsk 630090, Russia
^c Institute of Mathematics named after S. L. Sobolev SB RAS, pr. Acad. Koptyuga 4, Novosibirsk 630090, Russia

Abstract: A mathematical model of the functioning of the central regulatory circuit of gene networks of morphogenesis of drosophila mechanoreceptors is described, taking into account mutations of its genes. Computational experiments have been carried out showing the presence of a hierarchy of effects of CRK gene mutations on the production of ASC proteins.

Keywords: central regulatory circuit, gene network, mathematical model, parameter identification, computer modeling, fruit fly, achaete-scute complex, mutations.

UDC: 517.958:539.3

Received: 09.02.2023
Revised: 29.03.2023
Accepted: 27.04.2023

DOI: 10.33048/SIBJIM.2023.26.311

 English version: Journal of Applied and Industrial Mathematics, 2023, 17:3, 535–543