This article is cited in 6 papers

Principles of DNA architectonics: design of DNA-based nanoobjects

O. A. Vinogradova, D. V. Pyshnyi

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk

Abstract: The methods of preparation of monomeric DNA blocks that serve as key building units for the construction of complex DNA objects are described. Examples are given of the formation of DNA blocks based on native and modified oligonucleotide components using hydrogen bonding and nucleic acid-specific types of bonding and also some affinity interactions with RNA, proteins, ligands. The static discrete and periodic two- and three-dimensional DNA objects reported to date are described systematically. Methods used to prove the structures of DNA objects and the prospects for practical application of nanostructures based on DNA and its analogues in biology, medicine and biophysics are considered. The bibliography includes 195 references.

Received: 02.09.2011

DOI: 10.1070/RC2012v081n02ABEH004265

 English version: Russian Chemical Reviews, 2012, 81:2, 130–157

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