This article is cited in 89 papers

Nucleophilic substitution of the nitro group, fluorine and chlorine in aromatic compounds

V. M. Vlasov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistryof the Siberian Branch of Russian Academy of Sciences

Abstract: The published data on the comparative activities of the nitro group, fluorine and chlorine in aromatic nucleophilic substitution reactions are generalised and systematised. The factors influencing the relative activities of these substituents, viz., the structure of the substrate, the nature of the nucleophile and reaction conditions, are discussed. The synthetic applications and possible mechanisms of nucleophilic substitution of the nitro group, fluorine and chlorine in aromatic compounds are considered.

Received: 12.12.2002

DOI: 10.1070/RC2003v072n08ABEH000809

 English version: Russian Chemical Reviews, 2003, 72:8, 681–703

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