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Conformationally rigid cyclic α-amino acids in the design of peptidomimetics, peptide models and biologically active compounds

I. V. Komarov, A. O. Grigorenko, A. V. Turov, V. P. Khilya

National Taras Shevchenko University of Kyiv, Chemical Faculty

Abstract: A class of conformationally rigid cyclic α-amino acids that can be used in the synthesis of peptidomimetics, peptide models and biologically active compounds is surveyed. The rigid frameworks of such amino acids enable "fixation" of strictly defined torsion angles and hence prediction and deliberate tuning of the conformation of a polypeptide chain. Recent data on the structures and methods of the synthesis of such amino acids are presented.

Received: 18.03.2004

DOI: 10.1070/RC2004v073n08ABEH000912

 English version: Russian Chemical Reviews, 2004, 73:8, 785–810

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