This article is cited in 35 papers

BODIPY derivatives as fluorescent reporters of molecular activities in living cells

V. I. Martynov, A. A. Pakhomov

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow

Abstract: Fluorescent compounds have become indispensable tools for imaging molecular activities in the living cell. 4,4-Difluoro-4-bora-3a,4a-diaza-$s$-indacene (BODIPY) is currently one of the most popular fluorescent reporters due to its unique photophysical properties. This review provides a general survey and presents a summary of recent advances in the development of new BODIPY-based cellular biomarkers and biosensors. The review starts with the consideration of the properties of BODIPY derivatives required for their application as cellular reporters. Then review provides examples of the design of sensors for different biologically important molecules, ions, membrane potential, temperature and viscosity defining the live cell status. Special attention is payed to BODPY-based phototransformable reporters.
The bibliography includes 339 references.

Keywords: fluorescent dye; BODIPY; fluorescence microscopy; intracellular sensor.

Received: 23.07.2020

DOI: 10.1070/RCR4985

 English version: Russian Chemical Reviews, 2021, 90:10, 1213–1262

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