This article is cited in 87 papers

Chitosan and its derivatives: vectors in gene therapy

A. S. Kritchenkov^ab, S. Andranovitš^c, Yu. A. Skorik<sup>ad

a</sup> Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg
^b St. Petersburg State University, Institute of Chemistry
^c University of Vienna, Austria
^d Institute of Experimental Medicine, Federal V. A. Almazov North-West Medical Research Centre, Saint Petersburg

Abstract: The review deals with the use of chitosan and its derivatives as vectors for delivery of nucleic acids in gene therapy. Factors influencing the transfection efficiency of chitosan-based polyplexes (molecular weight, the degree of deacetylation, pH, type of chemical modification, type of transfected cells) are discussed. Particular attention is paid to methods of chemical modification of chitosan (covalent hydrophilic and hydrophobic modification and non-covalent modification), which are able to increase the transfection efficiency and to provide targeted delivery of nucleic acids.
The bibliography includes 151 references.

Received: 17.02.2016

DOI: 10.1070/RCR4636

 English version: Russian Chemical Reviews, 2017, 86:3, 231–239

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