This article is cited in 7 papers

Inorganic pyrophosphatases: structural diversity serving the function

V. R. Samygina<sup>ab

a</sup> Institute of Cristallography Russian Academy of Sciences, Moscow
^b National Research Centre "Kurchatov Institute", Moscow

Abstract: The review is devoted to ubiquitous enzymes, inorganic pyrophosphatases, which are essential in all living organisms. Despite the long history of investigations, these enzymes continue to attract interest. The review focuses on the three-dimensional structures of various representatives of this class of proteins. The structural diversity, the relationship between the structure and some properties of pyrophosphatases and various mechanisms of enzyme action related to the structural diversity of these enzymes are discussed. Interactions of pyrophosphatase with other proteins and possible practical applications are considered.
The bibliography includes 56 references.

Received: 06.11.2014

DOI: 10.1070/RCR4529

 English version: Russian Chemical Reviews, 2016, 85:5, 464–476

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