This article is cited in 38 papers

Ion-selective electrodes in medicinal drug determination

S. V. Kharitonov

State Technological Institute of St. Petersburg (Technical University)

Abstract: Data published in the past 10 years on the use of ion-selective electrodes in direct potentiometry and potentiometric titration for the determination of organic medicinal drugs are analysed. In the vast majority of cases, ion-sensitive membranes contain associates of drug cations or anions with appropriate counter-ions. The theoretical approaches to optimisation of the characteristics of ion-selective electrodes are discussed. The mechanism of electrode response generation for neutral and charged carriers of organic ions is considered.

Received: 10.10.2006

DOI: 10.1070/RC2007v076n04ABEH003670

 English version: Russian Chemical Reviews, 2007, 76:4, 361–395

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