This article is cited in 9 papers

HIV-1 integrase inhibitors as new components of antiviral therapy

T. A. Prikazchikova^a, A. M. Sycheva^b, Yu. Yu. Agapkina^b, D. A. Aleksandrov^a, M. B. Gottikh<sup>a

a</sup> Lomonosov Moscow State University, Belozersky Research Institute of Physico-Chemical Biology
^b Lomonosov Moscow State University, Faculty of Chemistry

Abstract: Structural and functional features of HIV-1 integrase are considered and the state of the art in the quest for effective inhibitors of this enzyme is reported. The major classes of integrase inhibitors with known mechanisms of action as well as their in vitro and in vivo inhibitory activities are presented.

Received: 24.01.2008

DOI: 10.1070/RC2008v077n05ABEH003779

 English version: Russian Chemical Reviews, 2008, 77:5, 421–434

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