This article is cited in 25 papers

Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs

I. V. Serkov^a, V. V. Bezuglov<sup>b

a</sup> Institute of Physiologically Active Compounds RAS, Chernogolovka
^b M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow

Abstract: The modern trend in medicinal chemistry consists of designing multifunctional drugs with a wide variety of targets. This review considers one of the ways of development of such drugs, namely, the introduction of nitrogen monoxide-generating fragments into molecules of known drugs. Examples of syntheses and the results of biological activity assays are shown for O-nitro derivatives of various drugs.

Received: 16.01.2009

DOI: 10.1070/RC2009v078n05ABEH004024

 English version: Russian Chemical Reviews, 2009, 78:5, 407–429

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