This article is cited in 51 papers

Nucleophilic substitution at the halogen atom (halogenophilic reactions)

P. K. Sazonov, G. A. Artamkina, I. P. Beletskaya

Lomonosov Moscow State University, Faculty of Chemistry

Abstract: The key features of halogenophilic reactions defining their role in organic chemistry are considered. The results of studies of mechanisms involving a nucleophilic attack at the halogen atom (S_N2Hal) are summarized. The main mechanistic evidence comes from the studies of halogen–metal exchange reactions. Primary attention is paid to the role of halogenophilic reaction as a competing process or a concealed mechanism in ordinary nucleophilic substitution reaction at carbon atoms. The bibliography includes 249 references.

Received: 17.03.2011

DOI: 10.1070/RC2012v081n04ABEH004216

 English version: Russian Chemical Reviews, 2012, 81:4, 317–335

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