This article is cited in 3 papers

Chemical approaches to the study of supramolecular biological structures with chromatin as an example

D. G. Knorre, N. D. Kobets

Novosibirsk Institute of Bioorganic Chemistry, Siberian Branch of the Russian Academy of Sciences

Abstract: Chemical approaches to the study of the chromatin structure and certain aspects of its functioning are reviewed. The main attention is given primarily to those based on the method of 'zero-length cross-linking' aimed at the investigation of the structure of histone complexes within nucleosomes and of the interactions of histones and other proteins with chromosomal DNA. The changes in the nucleosome structure during chromatin transcription are discussed. Recent data on the chemical modification of DNA and several chromatin proteins with reactive oligonucleotide derivatives are considered and analysed. The bibliography includes 89 references.

UDC: 577.113.7

Received: 02.07.1998

DOI: 10.1070/RC1999v068n04ABEH000473

 English version: Russian Chemical Reviews, 1999, 68:4, 333–342

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