This article is cited in 5 papers

Synthesis of reactive nucleic acid analogues and their application for the study of structure and functions of biopolymers

I. E. Kanevskii, S. A. Kuznetsova

M. V. Lomonosov Moscow State University, Department of Chemistry

Abstract: Data on the synthesis of reactive derivatives of nucleic acid analogues and their application for the study of structure and functions of biopolymers are generalised. The main types of such analogues including photoactivated reagents containing azidoaryl, halogeno, and thiol groups, psoralen and its derivatives, platinum-based reagents, and nucleic acid analogues containing substituted pyrophosphate or acyl phosphate internucleotide groups are presented. The mechanisms of interaction of these compounds with proteins and nucleic acids are considered. The prospects for the in vivo application of reactive nucleic acids in various systems are discussed. The bibliography includes 76 references.

UDC: 547.863.32; 577.113.4

Received: 09.09.1997

DOI: 10.1070/RC1998v067n07ABEH000394

 English version: Russian Chemical Reviews, 1998, 67:7, 617–631

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