This article is cited in 17 papers

Natural compounds of the strobilurin series and their synthetic analogues as cell respiration inhibitors

V. V. Zakharychev, L. V. Kovalenko

D. Mendeleev University of Chemical Technology of Russia, Moscow

Abstract: A group of fungicidal antibiotics, β-methoxyacrylic acid derivatives (strobilurins, oudemansins, and myxothiazols), their producers, and mechanisms of action are considered. The fungicidal activity of these compounds is based on the suppression of cell respiration of fungi in the bc₁-complex of cytochromes. They also manifest other biological activities that are not always coupled with inhibition of respiration. Studies of the structure of the natural methoxyacrylates has made it possible to create a novel class of synthetic agricultural fungicides with enhanced stability, high activity, and a broad spectrum of action. The main regularities of the structure–activity relationship and methods of synthesis of these compounds are discussed. The bibliography includes 159 references.

UDC: 577.158.8.04:632.952

Received: 10.10.1997

DOI: 10.1070/RC1998v067n06ABEH000426

 English version: Russian Chemical Reviews, 1998, 67:6, 535–544

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