This article is cited in 17 papers

Michael synthesis of esters of β-amino acids: stereochemical aspects

N. N. Romanova, A. G. Gravis, Yu. G. Bundel'

M. V. Lomonosov Moscow State University, Department of Chemistry

Abstract: Published data dealing with the synthesis of esters of β-amino acids by nucleophilic addition of amines and metal amides to esters of α,β-unsaturated carboxylic acids are considered. Information on the influence of various factors on the chemical yield and diastereoselectivity of the Michael reaction is discussed systematically. The bibliography includes 70 references.

UDC: 541.63:542.955:547.26'11.466.318

Received: 17.04.1996

DOI: 10.1070/RC1996v065n12ABEH000244

 English version: Russian Chemical Reviews, 1996, 65:12, 1083–1092

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