This article is cited in 9 papers

Radiation-induced inactivation of proteolytic enzymes

M. A. Orlova

M. V. Lomonosov Moscow State University, Department of Chemistry

Abstract: Data on the mechanism of the inactivation of proteases under various conditions and the possible applications of these processes are surveyed. Serine, sulfhydryl, acid, and metal containing proteases are considered. Attention is concentrates on the conformation changes in radiolytic processes: their dependence on the pH of the medium and the correlations with the change in the aminoacid composition of the enzymes. The bibliography includes 90 references.

UDC: 541.15

Received: 04.02.1993

DOI: 10.1070/RC1993v062n05ABEH000029

 English version: Russian Chemical Reviews, 1993, 62:5, 493–508

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