This article is cited in 6 papers

Biophotonics

Method of measuring blood oxygenation based on spectroscopy of diffusely scattered light

M. S. Kleshnin, A. G. Orlova, M. Yu. Kirillin, G. Yu. Golubyatnikov, I. V. Turchin

Institute of Applied Physics of the Russian Academy of Sciences, Nizhnii Novgorod

Abstract: A new approach to the measurement of blood oxygenation is developed and implemented, based on an original two-step algorithm reconstructing the relative concentration of biological chromophores (haemoglobin, water, lipids) from the measured spectra of diffusely scattered light at different distances from the radiation source. The numerical experiments and approbation of the proposed approach using a biological phantom have shown the high accuracy of the reconstruction of optical properties of the object in question, as well as the possibility of correct calculation of the haemoglobin oxygenation in the presence of additive noises without calibration of the measuring device. The results of the experimental studies in animals agree with the previously published results obtained by other research groups and demonstrate the possibility of applying the developed method to the monitoring of blood oxygenation in tumour tissues.

Keywords: diffuse optical spectroscopy, blood oxygenation, diffuse reflection, reconstruction of tissue composition.

Received: 30.12.2016
Revised: 21.02.2017

 English version: Quantum Electronics, 2017, 47:4, 355–360

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