This article is cited in 4 papers

Optical methods in biology and medicine

Optical diagnostics of tumour cells at different stages of pathology development

L. S. Shcheglova^a, L. L. Abramova^b, V. S. Maryakhina<sup>a

a</sup> Orenburg State University
^b Orenburg State Agrarian University, Orenburg

Abstract: The differences in optical and biophysical properties between the cells of mammary gland tumour extracted from tumours of different diameter are described. It is shown that the spectral and spectrokinetic properties of fluorescent probes in the cells extracted from the tumours 1 – 3 cm in diameter are essentially different. Thus, the extinction coefficient of rhodamine 6G gradually increases with the pathology development. At the same time the rate of interaction of the triplet states of molecular probes with the oxygen, diluted in the tumour cells cytoplasm, decreases with the growth of the tumour capsule diameter. The observed regularities can be due to the changes in the cell structure, biochemical and biophysical properties. The reported data may be useful for developing optical methods of diagnostics of biotissue pathological conditions.

Keywords: fluorescence diagnostics, tumour, molecular probes, long-term luminescence.

PACS: 42.62.Be, 87.19.xj, 87.64.kv

Received: 23.03.2013
Revised: 16.07.2013

 English version: Quantum Electronics, 2013, 43:11, 1088–1090

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