M. A. Vilensky, O. V. Semyachkina-Glushkovskaya, P. A. Timoshina, J. V. Kuznetsova, I. A. Semyachkin-Glushkovskii, D. N. Agafonov, V. V. Tuchin, “Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress”, Kvantovaya Elektronika, 2012, Volume 42, Number 6,Pages <nobr>489

This article is cited in 8 papers

Biophotonics

Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress

M. A. Vilensky^a, O. V. Semyachkina-Glushkovskaya^a, P. A. Timoshina^a, J. V. Kuznetsova^a, I. A. Semyachkin-Glushkovskii^a, D. N. Agafonov^a, V. V. Tuchin^abc

^a Saratov State University
^b University of Oulu, Finland
^c Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov

Abstract: The results of experimental approbation of the method of laser full-field speckle-imaging for monitoring the changes in blood microcirculation state of the brain cortex of laboratory rats under the conditions of developing stroke and administration of vasodilating and vasoconstrictive agents are presented. The studies aimed at the choice of the optimal conditions of speckle-image formation and recording were performed and the software implementing an adaptive algorithm for processing the data of measurements was created. The transfer of laser radiation to the probed region of the biotissue was implemented by means of a silica-polymer optical fibre. The problems and prospects of speckle-imaging of cerebral microcirculation of blood in laboratory and clinical conditions are discussed.

Keywords: laser speckles, full-field method, contrast of speckleimages, adaptive algorithm, microcirculation, cerebral blood flow.

PACS: 87.57.-s, 87.19.U-, 42.30.Ms

Received: 23.04.2012