È. A. Genina, L. E. Dolotov, A. N. Bashkatov, G. S. Terentyuk, G. N. Maslyakova, E. A. Zubkina, V. V. Tuchin, I. V. Yaroslavsky, G. B. Altshuler, “Fractional laser microablation of skin aimed at enhancing its permeability for nanoparticles”, Kvantovaya Elektronika, 2011, Volume 41, Number 5,Pages <nobr>396

This article is cited in 25 papers

Optical technologies in biophysics and medicine

Fractional laser microablation of skin aimed at enhancing its permeability for nanoparticles

È. A. Genina^a, L. E. Dolotov^a, A. N. Bashkatov^a, G. S. Terentyuk^b, G. N. Maslyakova^c, E. A. Zubkina^a, V. V. Tuchin^a, I. V. Yaroslavsky^d, G. B. Altshuler^d

^a OBP Research-Educational Institute of Optics and Biophotonics, Saratov State University
^b LLC "The First Veterinary Clinic", Saratov
^c Saratov State Medical University named after V. I. Razumovsky
^d Palomar Medical Technologies, Inc., Birlington, USA

Abstract: A new method for delivering nanoparticles into the skin using the fractional laser microablation of its surface and the ultrasonic treatment is proposed. As a result of in vitro and in vivo studies, it is shown that the 290-nm laser pulses with the energy from 0.5 to 3.0 J provide the penetration of nanoparticles of titanium dioxide with the diameter ~100 nm from the skin surface to the depth, varying from 150 to 400 μm. Histological testing of the skin areas, subjected to the treatment, shows that the particles stay in the dermis at the depth up to 400 μm no less than for three weeks.

PACS: 87.16.dp, 79.20.Eb, 87.64.Cc, 87.80.Dj

Received: 04.04.2011