O. V. Ulianova, S. S. Ul'yanov, P. Li, Q. Luo, “Estimation of reactogenicity of preparations produced on the basis of photoinactivated live vaccines against brucellosis and tularaemia on the organismic level. 1. Using the LASCA method”, Kvantovaya Elektronika, 2011, Volume 41, Number 4,Pages <nobr>340

This article is cited in 17 papers

Optical technologies in biophysics and medicine

Estimation of reactogenicity of preparations produced on the basis of photoinactivated live vaccines against brucellosis and tularaemia on the organismic level. 1. Using the LASCA method

O. V. Ulianova^ab, S. S. Ul'yanov^a, P. Li^c, Q. Luo^c

^a Saratov State University named after N. G. Chernyshevsky
^b Saratov State Agrarian University named after N. I. Vavilov
^c Huazhong University of Science and Technology, Wuhan, China

Abstract: A new method of photoinactivation of bacteria aimed at producing prototypes of vaccine preparations against extremely dangerous infections is described. The reactogenicity of the new prophylactic preparations was studied using the laser speckle contrast analysis (LASCA). The performed experimental studies show that bacterial suspensions, irradiated using different regimes of photoinactivation, do not cause detrimental effect on the blood microcirculation in laboratory animals.

PACS: 05.45.Df, 42.30.Ms, 87.64.Aa, 87.64.Cc

Received: 25.02.2011