T. D. Khokhlova, I. M. Pelivanov, O. A. Sapozhnikov, V. S. Solomatin, A. A. Karabutov, “Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments”, Kvantovaya Elektronika, 2006, Volume 36, Number 12,Pages <nobr>1097

This article is cited in 28 papers

Special issue devoted to multiple radiation scattering in random media

Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments

T. D. Khokhlova^a, I. M. Pelivanov^a, O. A. Sapozhnikov^b, V. S. Solomatin^a, A. A. Karabutov^a

^a International Laser Center of Moscow State University
^b Lomonosov Moscow State University, Faculty of Physics

Abstract: The possibility of using the opto-acoustic (OA) method for monitoring high-intensity ultrasonic therapy is studied. The optical properties of raw and boiled liver samples used as the undamaged model tissue and tissue destroyed by ultrasound, respectively, are measured. Experiments are performed with samples consisting of several alternating layers of raw and boiled liver of different thickness. The position and transverse size of the thermal lesion were determined from the temporal shape of the OA signals. The results of measurements are compared with the real size and position of the thermal lesion determined from the subsequent cuts of the sample. It is shown that the OA method permits the diagnostics of variations in biological tissues upon ultrasonic therapy.

PACS: 87.50.Kk, 43.35.Sx

Received: 25.05.2006
Revised: 05.07.2006