This article is cited in 3 papers

Large Systems

Gibbs Field Approach for Evolutionary Analysis of Regulatory Signal of Gene Expression

V. A. Lyubetsky, E. A. Zhizhina, L. I. Rubanov

A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences

Abstract: We propose a new approach to modeling a nucleotide sequence evolution subject to constraints on the secondary structure. The approach is based on the problem of optimizing a functional that involves both standard evolution of the primary structure and a condition of secondary structure conservation. We discuss simulation results in the example of evolution in the case of classical attenuation regulation.

UDC: 621.391.1

Received: 12.02.2008
Revised: 22.04.2008

 English version: Problems of Information Transmission, 2008, 44:4, 333–351

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