Mass-spectrometric online monitoring of metabolism for estimation of adequacy of anesthesia

A. Yu. Elizarov^a, A. I. Levshankov^b, I. I. Faizov^b, A. V. Shchegolev<sup>b

a</sup> Ioffe Institute, St. Petersburg
^b Kirov Medical Force Academy, St. Petersburg

Abstract: The possibility of using a mass-spectrometric method for estimation of the adequacy of anesthesia has been demonstrated. The method is based on online monitoring of metabolism by determining the CO$_2$/O$_2$ concentration ratio during expiration in each breathing cycle, which allows the patient’s response to surgical injury in the course of total anesthesia to be evaluated. The proposed method has been clinically tested using an electron-impact ionization mass spectrometer connected to the breathing circuit of an inhalation anesthesia machine. It is shown that, using this technique, the time of the patient’s organism response to drug correction of the adequacy of lung ventilation during anesthesia can be monitored online.

Received: 04.04.2012

 English version: Technical Physics Letters, 2012, 38:8, 729–735

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