Study of the effect of inactivating agents on the structure of adenovirus particles using small-angle X-ray scattering and transmission electron microscopy

D. A. Krylov^a, A. T. Tabarov^a, D. M. Danilenko^b, V. V. Vitkin<sup>a

a</sup> St. Petersburg National Research University of Information Technologies, Mechanics and Optics
^b Smorodintsev Research Institute of Influenza, Saint-Petersburg

Abstract: In this work, the effect of inactivating agents (formaldehyde and $\beta$-propiolactone) on the structure of viral particles was investigated using small-angle X-ray scattering and transmission electron microscopy. Data were obtained indicating the destruction of the natural structure of the adenovirus due to the effect of $\beta$-propiolactone. The results of this study may be useful in the development of vaccines.

Keywords: viruses, inactivation, small-angle X-ray scattering, synchrotron research.

Received: 17.03.2025
Revised: 03.07.2025
Accepted: 04.07.2025

DOI: 10.61011/PJTF.2025.19.61147.20315

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