Graphene-based biosensors for neurodegenerative dementia detection

N. M. Shmidt^a, A. S. Usikov^ab, S. V. Vorobyev^cad, A. Yu. Plekhanov^e, I. K. Ternovych^cd, A. D. Roenkov^b, M. V. Puzyk^f, E. I. Shabunina^a, E. V. Gushchina^a, S. P. Lebedev^a, A. A. Lebedev^a, A. N. Smirnov^a, S. Yu. Priobrazhenskii^a, E. M. Tanklevskaya<sup>a

a</sup> Ioffe Institute, St. Petersburg, Russia
^b Nitride Crystals Group, St. Petersburg, Russia
^c Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation, St. Petersburg, Russia
^d Federal State Budgetary Educational Institution of Higher Education Saint Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia
^e Smorodintsev Research Institute of Influenza, St. Petersburg, Russia
^f Herzen State Pedagogical University of Russia, St. Petersburg, Russia

Abstract: A comprehensive study of biosensors for $\beta$-amyloid and $\tau$-protein marker detection based on graphene films obtained by thermal decomposition of semi-insulating SiC has shown the possibility of doubling the biosensor response without using graphene functionalization. It has been found that one of the reasons for the low reproducibility of detection results and the decrease in the biosensor response is the aggregation of antibodies and proteins in defective areas of graphene.

Keywords: nanomaterials, graphene, biosensors, Alzheimer's disease.

Received: 26.08.2024
Revised: 26.08.2024
Accepted: 24.09.2024

DOI: 10.61011/PJTF.2025.03.59813.20091

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