A. T. Tabarov, D. A. Krylov, O. V. Andreeva, A. V. Smirnov, D. M. Danilenko, V. V. Vitkin, “Estimation of the size of SARS-CoV-2 viral particles based on Small-angle X-ray scattering data in the application for SERS spectroscopy”, Pisma v Zhurnal Tekhnicheskoi Fiziki, 2024, Volume 50, Issue 11,Pages <nobr>11

Estimation of the size of SARS-CoV-2 viral particles based on Small-angle X-ray scattering data in the application for SERS spectroscopy

A. T. Tabarov^a, D. A. Krylov^a, O. V. Andreeva^a, A. V. Smirnov^a, D. M. Danilenko^b, V. V. Vitkin^a

^a St. Petersburg National Research University of Information Technologies, Mechanics and Optics, St. Petersburg, Russia
^b Smorodintsev Research Institute of Influenza, St. Petersburg, Russia

Abstract: Using small-angle X-ray scattering (SAXS), the pairwise distance function of SARS-CoV-2 viral particles has been determined. The influence of surface proteins, which create a loosened structure on the virus surface, on the results of viral particle size determination is discussed. The obtained results are of interest for the development of selective SERS substrates for the diagnosis of coronavirus infection.

Keywords: Viruses, small-angle scattering, X-ray, synchrotron studies.

Received: 18.12.2023
Revised: 25.02.2024
Accepted: 26.02.2024

DOI: 10.61011/PJTF.2024.11.57902.19848