Production of gadolinium nanoparticles in a polymer matrix by a pulsed mechanical impact

A. I. Aleksandrov^a, S. B. Zezin^b, S. S. Abramchuk<sup>c

a</sup> N. S. Enikolopov Institute of Synthetic Polymer Materials RAS, Moscow, Russia
^b Lomonosov Moscow State University, Moscow, Russia
^c A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow, Russia

Abstract: In this study, superparamagnetic elemental-gadolinium nanoparticles 2 to 12 nm in size were for the first time obtained under a pulsed mechanical impact (rheological discharge explosion). The synthesis was carried out in one stage in an environmentally friendly (“green chemistry”) mode in a polymer matrix doped with the Gd(QH)$_3$ complex, where QH is a ligand based on 3,6 di-tert-butyl phenol that is an environmentally safe antioxidant. Emergence of these particles was confirmed by electron paramagnetic resonance, X-ray phase analysis and transmission electron microscopy. This synthesis may be a regarded as basis for further progress in producing gadolinium nanoparticles which can be used in neutron- and photon-capture therapy of malignant neoplasms with biological targeting using magnetic resonance imaging or computed tomography.

Keywords: gadolinium, nanoparticle, mechanical impact, neutron- and photon-capture therapy, malignant neoplasms.

Received: 22.12.2023
Revised: 29.01.2024
Accepted: 31.01.2024

DOI: 10.61011/PJTF.2024.10.57701.19850

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