This article is cited in 2 papers

Evaluation of cell viability in living tissue equivalents exposed to pulsed current with a DC offset

E. A. Shershunova^a, I. E. Rebrov^a, V. V. Mishchenko^b, A. I. Kryukov^b, E. A. Vorotelyak^c, O. S. Rogovaya<sup>c

a</sup> Institute of Problems of Electrophysics of the Russian Academy of Sciences, St. Petersburg
^b Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow
^c Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow

Abstract: An electrophysical apparatus for combined electroporation and iontophoresis treatment of biological membranes is described. Estimates of cell viability in living tissue equivalents exposed to pulsed current with a dc offset are provided. The values of the electrophysical pulse characteristics compatible with the viability of cells in the living tissue equivalents have been determined. The obtained data suggest that these electrophysical parameters could be used for transportation of pharmaceutical compounds through an equivalent of the round window membrane of the cochlea. A technique of drug administration across biological barriers can be developed based on pulsed electric field equipment to enable drug delivery into the inner ear.

Keywords: pulse current, biological membranes, cell viability.

Received: 29.10.2020
Revised: 09.02.2021
Accepted: 02.04.2021

DOI: 10.21883/PJTF.2021.13.51117.18606

 English version: Technical Physics Letters, 2021, 47:9, 681–684

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