Abstract:
A comparative study of the influence of an aqueous medium properties on the aggregation of dimegine, photoditazine and radachlorin was carried out. A nonlinear dependence of the molar extinction on the concentration of the photosensitizer in solution was noted, moreover to varying degrees for the dosage form of the solution and solutions prepared using lyophilized photosensitizer powders. It has been shown that the use of surfactants (Pluronic F-127 and polyvinylpyrrolidone) within certain limits reduces the problems associated with the aggregation of the studied photosensitizers.
Keywords:photosensitizer, singlet oxygen, porphyrins, dimegine, aggregates, dimers, absorption spectra.
