This article is cited in 3 papers

Applied optics

Spectrophotometric characteristics of immunoglobulin conjugates for diagnostics of the agents of particularly dangerous infections

A. N. Spitsyn^a, D. V. Utkin^a, M. N. Kireev^a, M. V. Ovchinnikova^a, O. S. Kuznetsov^a, P. S. Erokhin^a, V. I. Kochubey<sup>bc

a</sup> Mikrob Russian Antiplague Research Institute, Saratov, Russia
^b Saratov State University
^c Tomsk State University

Abstract: The possibility of using spectrophotometric analysis to characterize fluorescent immunoglobulins as a control method was considered. A comparative analysis of the optical properties of fluorescent immunoglobulin preparations and their constituent components - immunoglobulins, fluorochrome was carried out. The results suggest that the proposed methodological approach of optical detection of labeled immunoglobulin molecules is promising for controlling the preparation of conjugates used in the formulation of immunological reactions to identify specific antigens of pathogens of particularly dangerous infections.

Keywords: spectrophotometry, immunoglobulins, conjugates, FITC.

Received: 25.02.2019
Revised: 16.04.2019
Accepted: 28.10.2019

DOI: 10.21883/OS.2020.03.49071.76-19

 English version: Optics and Spectroscopy, 2020, 128:3, 417–421

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