Proceedings of The XXVIII Annual International Conference "Saratov Fall Meeting 2024", September 23-27, 2024
Ultraviolet, infrared and terahertz optics

Powerful terahertz radiation source for studying the effects on protein conformation

V. V. Teplyakov^a, O. P. Cherkasova^abc, M. M. Nazarov^a, M. R. Konnikova^ad, V. A. Tverdislov^d, P. M. Gotovtsev<sup>a

a</sup> National Research Centre "Kurchatov Institute", Moscow
^b Institute of Automation and Electrometry, Siberian Branch of Russian Academy of Sciences, Novosibirsk
^c Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk
^d Lomonosov Moscow State University, Faculty of Physics

Abstract: The effect of terahertz pulses with an energy of 10 $\mu$J, a peak field of 1.3 MV/cm, and a spectrum from 1 to 6 THz on protein (bovine serum albumin) was investigated. The protein pre-pressed into a tablet was irradiated. The exposure time was 15 min. After irradiation, the protein was dissolved in water at a concentration of 1 mg/mL. UV spectroscopy in the range of 220–360 nm revealed a decrease in the molar extinction coefficient, which can be interpreted as a sign of structural changes in protein molecules under irradiation with terahertz radiation with the specified parameters.

Keywords: intensive terahertz radiation, effects, albumin, UV spectroscopy.

Received: 12.12.2024
Revised: 17.12.2024
Accepted: 07.04.2025

DOI: 10.61011/OS.2025.05.60798.22-25

Bibliographic databases:

•