Abstract:
In the paper the possibility of using radiopaque and magnetic resonance agents, which are already used in clinical practice, for optical clearing of biological tissues was investigated. In vivo measurements of the degree of tissue optical clearing and evaluation of the effectiveness of the studied agents were carried out in the area of the nail bed of a human finger using optical coherence tomography technique. It was shown that almost all the agents used are effective for optical clearing of the tissue in the studied area at certain depths. For example, after applying the gadovist$^\circledR$ magnetic resonance agent, the extinction coefficient of probing beam decreased by 16 $\pm$ 8% at a depth from 0 to 50 $\mu$m. When using visipaque$^\circledR$ radiopaque agent in combination with polypropylene glycol, the extinction coefficient decreased by 30 $\pm$ 13% for the same depth. The results of the work make it possible to expand application scope of radiopaque and magnetic resonance agents to optical clearing of tissues and visualization of capillaries.
Fulltext:
PDF file (640 kB)