Proceedings of The XXVIII Annual International Conference "Saratov Fall Meeting 2024", September 23-27, 2024
Biophotonics

Laser Doppler floumetry in assessing the function of the skin microvascular bed in white outbreed rats with diet-induced obesity

È. B. Popyhova, T. E. Pylaev

Saratov State Medical University named after V. I. Razumovsky

Abstract: Using the laser Doppler flowmetry method, the state of the microvasculature of the skin of the distal part of the hind limb of white outbred rats with nutritional obesity caused by a “cafeteria diet” was studied. It has been shown that nutritional obesity contributes to a decrease in perfusion, and also causes the development of subclinical metabolic inflammation and dyslipidemia, which are the pathogenetic basis of endothelial dysfunction and atherosclerosis, which increase the risk of cardiovascular diseases.

Keywords: nutritional obesity, microcirculation, laser Doppler flowmetry, inflammation, angiogenesis.

Received: 14.11.2024
Revised: 13.12.2024
Accepted: 07.04.2025

DOI: 10.61011/OS.2025.05.60786.19-25

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