This article is cited in 2 papers

Communications

Synthesis and cytotoxic activity of new annulated furazan derivatives

E. B. Rakhimova, V. Yu. Kirsanov, E. S. Meshcheryakova, L. U. Dzhemileva, V. A. D'yakonov, A. G. Ibragimov, U. M. Dzhemilev

Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: New 2,8-di(het)aryl-containing dioxadecaazadicyclopenta[e,l]pyrenes, furazan-annulated polyaza polycycles, have been synthesized by acid-catalyzed cyclocondensation of difurazanotetraazadecalin with formaldehyde and primary (het)arylamines. The cytotoxic activity of these compounds against tumor cell lines (Jurkat, K562, U937, HL60) has been estimated.

Keywords: heterocyclization, aza-acetalization, aminals, furazans, Brønsted acids, polycycles, 5,11-dioxa-2,3a,4,6,6b,8,9a,10,12,12bdecaazadicyclopenta[e,l]pyrenes, cytotoxic activity.

Language: English

DOI: 10.1016/j.mencom.2021.04.026

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