Communications

Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues

Yu. V. Kozlova^a, Z. G. Denieva^b, M. S. Zolotareva^a, U. A. Budanova^a, Yu. L. Sebyakin<sup>a

a</sup> M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, 119454 Moscow, Russian Federation
^b A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071 Moscow, Russian Federation

Abstract: New cationic amphiphiles based on L-lysine and leucine C₉–C₁₂ alkyl esters (including optical isomers and structural analogues) were obtained. The influence of certain modifications in them on the antimicrobial activity was evaluated. The lead compound (hydrotrifluoroacetate of L-lysyl-L-leucine decyl ester) showed the highest efficacy with minimum inhibitory concentrations of 0.19 and 0.39 μg ml^–1, which is less than that for the control antibiotics vancomycin and ampicillin.

Keywords: antimicrobial amphiphiles, modified lipodipeptides, lysine, leucine analogues, antibacterial activity, pore-like defects, D/L amino acids.

Received: 30.06.2025
Accepted: 26.09.2025

Language: English

DOI: 10.71267/mencom.7863